Extended Data Fig. 7: Quantification of P-selectin expression and FiVis targeting to SHH-MB tumors. | Nature Materials

Extended Data Fig. 7: Quantification of P-selectin expression and FiVis targeting to SHH-MB tumors.

From: P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Extended Data Fig. 7

(a) P-selectin expression in SHH-MB tumor tissue upon treatment with various doses of ionizing radiation. (b) Near-IR fluorescence intensities of FiVis nanoparticles in tumor regions (cerebellum) of SHH-MB mice treated with FiVis nanoparticles (10 mg/kg) and various doses of ionizing radiation. Data in (a, b) are means ± SEM. n = 3 mice per group; *P < 0.05, **P < 0.01, ***P < 0.001, (one-way ANOVA); ns, not significant. (c) Dual axis representation of P-selectin expression and FiVis nanoparticle fluorescence in SHH-MB tumor at corresponding irradiation doses. (d) Correlation analysis comparing P-selectin expression and uptake of FiVis nanoparticles observed in tumor.

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