Extended Data Fig. 3: Adaptive threshold for NIR signal analysis.
From: On-patient medical record and mRNA therapeutics using intradermal microneedles
(a) The number of NIR bits were counted using ImageJ (National Institutes of Health, USA) and adaptive threshold method for NIR signal retention analysis. The results were used for MNP architecture optimization. (b) The brightness of NIR bits were computed using ImageJ and adaptive threshold method for NIR signal intensity analysis. The results were used for MNP architecture optimization. (c) Application of an MNP on swine using a custom applicator. (d) Applied MNP footprint was imaged with a custom NIR imaging system and analyzed with adaptive threshold algorithms.
