Extended Data Fig. 1: Cross-sectional SARS-CoV-2 Ab responses.

a, IgM, IgA and IgG OD values against S glycoprotein, RBD and N protein are binned based on days post-onset of symptoms (POS) for 302 separate serum samples taken sequentially from 65 individuals. The data is grouped based on disease severity, 0–3 (black) and 4/5 (red). The mean OD value is shown for each time window for both the 0–3 (black line) and 4/5 (red line) severity groups. OD = optical density. b, ID₅₀ measured using the SARS-CoV-2 pseudotype neutralization assay are binned based on days post-onset of symptoms (POS). The data is grouped based on disease severity, 0–3 (black) and 4/5 (red). The mean ID₅₀ values are shown for each time window for both the 0–3 (black line) and 4/5 (red line) severity groups. The ELISA assays were conducted once. A subset of neutralization experiments (n=25) were conducted twice yielding similar results.