Extended Data Fig. 3: The proportion of pairs identical by descent (IBD) within populations from global locations. | Nature Microbiology

Extended Data Fig. 3: The proportion of pairs identical by descent (IBD) within populations from global locations.

From: Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Extended Data Fig. 3

Panels A-H show the proportion of pairs IBD plotted across the genome for parasites from different geographical regions (marked in the top left of each panel). For samples where >90% of the genomes are IBD, only one representative sample with the highest genotype rate was selected and used for IBD analysis. Sample numbers are shown in each panel. Chromosome boundaries are indicated with grey dashed vertical lines. The ___location of pfaat1 and pfcrt are indicated with red arrows on top of each panel. The chr 10 peak (West Africa, A) contains pfmspdbl2 associated with decreased sensitivity to halofantrine, mefloquine and lumefantrine69. The chr 8 peak (East Africa and Asia (C-H)) contains dihydropteroate synthase (sulfadoxine resistance)70 and the chr 12 peak (D-F) contains GTP cyclohydrolase I, a compensatory locus for antifolate drugs71. See also analyses by Amambua-Ngwa et al.17, Hendon et al.18, and Carrasquilla et al.19.

Back to article page