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The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation

Nature Nanotechnology volume 18, pages 1121–1123 (2023)Cite this article

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Reducing cancer-related deaths can only happen with a better understanding of cancer biology and the development of improved, new therapeutics and delivery mechanisms. Nearly all cancer research is dependent upon the models being used, the model’s accuracy, and appropriate validation and benchmarking. Here the need for such considerations is discussed in line with the goal of the Cancer Moonshot.

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Authors and Affiliations

  1. Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA

    Peter C. Searson

  2. Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA

    Peter C. Searson

  3. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA

    Peter C. Searson

  4. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, USA

    Peter C. Searson

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  1. Peter C. Searson
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Correspondence to Peter C. Searson.

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Searson, P.C. The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation. Nat. Nanotechnol. 18, 1121–1123 (2023). https://doi.org/10.1038/s41565-023-01486-0

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