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Balancing stealth and targeting to improve nanomedicine efficacy

Developing nanomedicines that avoid fast blood clearance while retaining targeting specificity in vivo is inherently challenging. Leveraging the individual biomolecular corona, optimizing the nature of targeting ligands and exploring alternative stealth formulations might be the key to engineering tailored nanomedicine approaches.

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Fig. 1: Strategies to mitigate biomolecular corona formation and anti-PEG antibody challenges in nanomedicine.

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Acknowledgements

Y.J. acknowledges support received through the ARC Discovery Early Career Researcher Award scheme (DE230101542). S.J.K. acknowledges support received through the NHMRC Investigator grant scheme (APP2016491).

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Correspondence to Yi Ju or Stephen John Kent.

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Nature Nanotechnology thanks the anonymous reviewers for their contribution to the peer review of this work.

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Ju, Y., Kent, S.J. Balancing stealth and targeting to improve nanomedicine efficacy. Nat. Nanotechnol. 20, 576–579 (2025). https://doi.org/10.1038/s41565-025-01926-z

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