Extended Data Fig. 7: DI shows a lack of in vivo toxicity.
From: Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
a, Schematic of DI administration for the analysis of succinate dehydrogenase (SDH) activity in the heart and the liver. b, SDH activity in the heart and the liver of mice treated as in a. Mean of n = 2 technical replicates. Representative data from two mice. c, Western blot of SDH and GAPDH in mitochondrial and cytoplasmic fractions from the heart and the liver of mice treated as in a. Representative of two mice. For gel source data, see Supplementary Fig. 1.
