Extended Data Fig. 10: Site-specific patterns of relapse in the IHC, PAM50 and IntClust subtypes. | Nature

Extended Data Fig. 10: Site-specific patterns of relapse in the IHC, PAM50 and IntClust subtypes.

From: Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

Extended Data Fig. 10

a, Left, percentages of patients with metastases at a given site in the IHC subtypes (bar plots, total numbers also indicated). Upright triangles indicate significant positive differences in that group with respect to the overall mean and inverted triangles indicate significant negative differences in that group with respect to the overall mean using simultaneous testing of all sites (see Methods). Location of metastatic sites is not anatomically accurate. Right, cumulative incidence functions (as 1 − Kaplan–Meier estimates) for each site of metastasis in the IHC subtypes. The same patient can have multiple sites of metastasis. b, As for a, but for the PAM50 subtypes. c, As for a, but for the IntClust subtypes. These analyses were done with the recurrent-events cohort. Female silhouettes are from the public-___domain human body diagrams at https://commons.wikimedia.org/wiki/Human_body_diagrams.

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