Extended Data Fig. 4: Identification of light-responsive cells. | Nature

Extended Data Fig. 4: Identification of light-responsive cells.

From: Dissociable dopamine dynamics for learning and motivation

Extended Data Fig. 4

a, Average waveforms of optogenetically identified dopamine neurons (negative voltage upwards). Average light-evoked waveforms are shown in blue and session-wide average waveforms are in black. All spikes within 10 ms of laser onset were used to construct light-evoked waveform average. Averaged waveforms are normalized to have similar total peak-valley voltages (see Supplementary Fig. 1 for individual voltage ranges). b, Session-wide average waveform for non-dopamine cells. c, Opto-tagging P value for all units plotted in log-scale, showing a strong bimodal distribution. To classify cells as light-responsive we used a threshold of P < 0.001. d, Times to first spike after laser onset, showing mean for each identified dopamine neuron, and standard deviation (jitter).

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