Extended Data Fig. 8: Hierarchical clustering tree produced by fineSTRUCTURE.
From: Exome sequencing of Finnish isolates enhances rare-variant association power
We identified 16 subpopulations within the FinMetSeq dataset by applying a haplotype-based clustering algorithm, fineSTRUCTURE, on 2,644 unrelated individuals born by 1955 whose parents were both born in the same municipality (Methods). Each subpopulation is named based on the most common parental birth ___location among its members. Kai, Kainuu; Lap, Lapland; NKa, North Karelia; NOs, North Ostrobothnia; NSv, North Savonia; SOs, South Ostrobothnia; SuK, Surrendered Karelia. A map of Finland with regions labelled is supplied for reference. If multiple subpopulations share the same ___location label, the subpopulation is further distinguished with a numeral. NSv3 is used as an internal reference for the enrichment analysis. See Supplementary Table 17 for more detailed demographic descriptions of each subpopulation.
