Extended Data Fig. 6: Gene-based association of extremely rare variants in ALDH1L1 with glycine levels.
From: Exome sequencing of Finnish isolates enhances rare-variant association power
Top, the distribution of the covariate-adjusted and inverse-normal transformed phenotype. Bottom, the association statistics for each variant included in the gene-based test, along with the trait value for minor allele carriers of each variant (orange triangles). SV.P is the P value from the analysis of each variant in a single-variant analysis. The number of independent individuals in the analysis is 8,206.
