Extended Data Fig. 7: RNA maps for alternative 5′ and 3′ splice sites.
From: A large-scale binding and functional map of human RNA-binding proteins
a, b, Inner heatmaps indicate enrichment at RBP-responsive alternative 5′ splice site (a) and alternative 3′ splice site (b) events relative to native alternative 5′ splice site events for all RBPs with eCLIP and KD–RNA-seq data that showed a minimum of 50 significantly changing events upon knockdown. The region shown extends 50 nt into exons and 300 nt into introns. Outer heatmaps indicate positions at which the signal exceeds the 0.5–99.5% confidence interval obtained by 1,000 random samplings of the same number of events from the native alternative 5′ or 3′ splice site control sets, respectively, without multiple hypothesis correction.
