Extended Data Fig. 9: Comparison between RBP DNA and RNA association.
From: A large-scale binding and functional map of human RNA-binding proteins

a, Relative enrichment of overlap between RBP ChIP–seq peaks and peaks for indicated histone modifications, column-normalized by ‘scale’ in the R heatmap function. b, c, Jaccard indexes between ChIP–seq peaks of different RBPs at promoter regions (bottom left) or non-promoter regions (top right) are displayed as heatmaps for HepG2 (b) and K562 cells (c). d, A representative genomic region showing eCLIP and ChIP–seq signal for HNRNPK, PCBP2 and PCBP1 proteins in HepG2 cells. One replicate is shown; similar results were observed in a second biological replicate. e, Left, heatmap indicates the fraction of genes (extended 500 nt upstream of the TSS and 500 nt downstream of the TTS) overlapped by a ChIP–seq peak for each RBP for the set of genes in seven bins of increasing gene expression from RNA-seq (x-axis) in HepG2 cells. Middle, right, bars indicate the mean odds ratio for overlap between RBP ChIP–seq peak presence and differentially expressed genes (middle) or significant alternative splicing changes (right) upon knockdown of the same RBP relative to 100 random samplings of genes with similar expression levels. *P < 0.05 as determined by 100 random samplings of genes with similar expression levels, with no adjustment for multiple hypotheses.