Extended Data Fig. 6: Unsupervised multi-omics factor integration analysis of MBSHH.
From: Germline Elongator mutations in Sonic Hedgehog medulloblastoma
a, Overview of input samples and data types. b, Summary of variance in latent factors (LF1–LF4) across data types. c, Somatic and germline gene alterations that contribute to latent factor 1 (LF1). d, Association between germline ELP1 mutation status and LF1 score (n = 16 patients). P value was calculated using a two-sided Mann–Whitney U-test. Box plots are as defined in Fig. 1g. e, Functional enrichment of LF1-ranked proteins and mRNAs.
