Extended Data Fig. 9: Potential mechanisms of tissue-specific diseases.
From: A reference map of the human binary protein interactome
a, Histogram of the number of Mendelian diseases showing symptoms in several tissues. b, Test for enrichment of causal proteins associated with tissue-specific Mendelian diseases to interact with TiP proteins of affected tissues. c, Network neighbourhood of uniformly expressed causal proteins of tissue-specific diseases found to interact with TiP proteins in HuRI, indicating PPI perturbation by mutations. d, Causal genes split by mutation found to perturb PPI to TiP protein (dashed) or not (solid). e, Expression profile of PNKP and interactors in brain tissues and PPI perturbation pattern of disease causing (Glu326Lys) and benign (Pro20Ser) mutation. Yeast growth phenotypes on SC-Leu-Trp (top) or SC-Leu-Trp-His+3AT media (bottom) are shown; green or grey protein symbols denote preferentially or not expressed, respectively.
