Extended Data Fig. 8: Structural models of A3SL mut 1 and A3SL mut 4.
From: Determination of RNA structural diversity and its role in HIV-1 RNA splicing
a, Structural models for A3SL mut 1 derived from n = 1 experiment, after DREEM clustering. Pink box, region of mutations; blue box, splice site. Exonic splicing enhancer (ESE) and exonic splicing silencer (ESS) binding sites are shown. b, Structural models made using DMS-MaPseq data from HEK293T cells transfected with Δvpr HIV-1NHG A3SL mut 4. Dark blue box, sequence of the A3 splice site; pink box, ___location of the mutations. Splice enhancer and suppressor binding sites are highlighted; purple, ESS2p; blue, ESEtat; orange, ESE2; and green, ESS2. Percentages of each cluster come from n = 1 experiment.
