Extended Data Fig. 1: Sequence alignment of ACE2 proteins (1–420) from human, macaque, hamster and mouse.

Asterisks denote amino acid residues of human ACE2 that have been shown by structural analysis to interact with the receptor-binding ___domain of SARS-CoV-2³⁶. Amino acid residues that are important for the interaction between human ACE2 and receptor-binding ___domain of SARS-CoV are highlighted by red boxes³⁷.