Extended Data Fig. 10: Relevance for COVID-19 and GWAS studies.

a, Global expression (log₂FC) of ACE2 in all cardiac cells. b–d, Gene expression of ACE2, TMPRSS2, CTSB and CTSL in cardiomyocytes (b), FBs (c) and vascular cells (d). e, Multiplexed smFISH expression of DCN (cyan), KCNJ8 (green) and ACE2 (red), nuclei are DAPI-stained (dark blue) marking fibroblasts (#; expression of DCN) and pericytes (*; co-expression of DCN and KCNJ8) in right ventricular tissue section. Scale bars, 5 μm. For statistics and reproducibility, see Methods. f, The colour coding of the heat map shows the −log₁₀(P value) of the MAGMA GWAS enrichment analysis for the association between cell type-specific expression (y axis) and GWAS signals (x axis). The cell types refer to the subcluster annotations and GWAS studies refer to Supplementary Table 27. AF, atrial fibrillation; CAD, coronary artery disease; HF, heart failure; HR, heart rate; HT, hypertension; LVD, left ventricular diameter; NICM, non-ischaemic cardiomyopathy; PR, PR interval; PWAVE, P-wave duration; T2D, type 2 diabetes; QRS, QRS complex duration; QT, QT interval. Dots mark significant associations (FDR < 10%). The colour of the dots indicates the type of association as determined by pairwise conditional analysis (green: independent association, blue: partially jointly explained with other cell types, grey: explained away by other cell types). Data are available in Supplementary Table 28.