Extended Data Fig. 1: Overview of the dataset.

a, Cellular compartments targeted for profiling by BioID. Bold numbers on the schematic correspond to the indices in the legend. Italicized numbers in brackets next to the compartment name indicate the number of baits used to profile that compartment after quality control. b, Bait similarity and localization. The Jaccard index was calculated between each pair of baits in the core dataset using the list of high confidence (1% FDR) interactors. Baits were clustered using the Euclidean distance and complete linkage method, and clusters optimized using the CBA package in R. The colour gradient next to the bait labels indicates whether a bait shares an expected localization with both adjacent baits (red), one adjacent bait (light red) or neither adjacent bait (white). Major clusters were manually annotated on the basis of the expected localization of the components.