Extended Data Fig. 6: Ligand-binding ___domain sequence alignment and ___domain organization of ApoER2 constructs. | Nature

Extended Data Fig. 6: Ligand-binding ___domain sequence alignment and ___domain organization of ApoER2 constructs.

From: VLDLR and ApoER2 are receptors for multiple alphaviruses

Extended Data Fig. 6

a, Sequence alignment of the Homo sapiens, Mus musculus, Equus caballus, and Sturnus vulgaris ApoER2 ligand binding domains. The LDLR class A (LA) repeats contained in each protein are shown in parentheses. The ___domain numbering is based on the human sequence shown. b, Schematic representation of the ectodomains of ApoER2 constructs used in this study. In mammals, exon regions encoding LA repeats 4-6 are almost exclusively spliced out, while the predominant avian isoforms retain these repeats14. Panel (a) was generated using ESPrit 3.074.

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