Extended Data Fig. 4: Clinical features of hamsters and ferrets.
From: Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta
(a–c) Syrian hamsters were inoculated with comparable genome equivalent mixture of either wt-S614G and Beta (a), Alpha and Beta (b), or wt-S614G and Alpha (c). In hamsters, body weight was monitored daily until 13 dpi, afterwards every two days until 21 dpi and plotted relative to bodyweight of day 0. The dotted line indicates the humane endpoint criterion of 20% body weight loss from initial bodyweight at which hamsters were promptly euthanized for animal welfare reasons. (d, e) Ferrets were inoculated intranasally with an equal mixture of wt-S614G and Alpha. Body weight (d) and temperature (e) were monitored daily in ferrets until 12 dpi, and afterwards every 2 days. Grey dotted lines in e indicate the physiologic range for body temperature in ferrets.
