Extended Data Fig. 4: Mediation of the relationship between shet burden and childlessness by various disorders.
From: Reduced reproductive success is associated with selective constraint on human genes
Plotted is the deletion and PTV meta-analysis -log10 P value for the association between shet burden and having children, corrected by one of 1,294 ICD-10 codes from a combination of general practitioner, hospital episode records, and self-reported conditions (left) or hospital episode records alone (right) separately for males (top) and females (bottom). Remaining ICD-10 codes at different levels on the ICD-10 hierarchy not displayed here are plotted in Supplementary Figs. 8 and 9. Results are ordered first by ICD-10 chapter (x-axis) and then by increasing -log10 P value (y-axis). The arrow for code Z37 indicates the point is below the scale of the y-axis with -log10 P value indicated in parentheses. Visual outliers are labelled and do not imply a significant change in the effect size of shet on childlessness.
