Extended Data Fig. 7: Cell type definition and gene ontology enrichment analysis of DOCK2 co-expression gene module in the PBMC single cell analysis.
From: DOCK2 is involved in the host genetics and biology of severe COVID-19
(a) Violin plots showing the expression distribution of selected canonical cell markers in the 12 clusters of PBMC. The rows represent selected marker genes and the columns represent clusters with the same color as in Fig. 2d. (b) Violin plots showing the expression distribution of selected canonical cell markers in the 5 clusters of innate immune cell clusters, shown in the same color as in Fig. 2h. (c) Tile plot showing percentage concordance between the manually annotated 12 clusters and Azimuth annotation. (d) The top 25 enriched biological processes by gene ontology (GO) analysis of DOCK2 co-expression gene module identified by weighted gene co-expression network analysis (WGCNA) in the non-classical monocytes of COVID-19 patients, where DOCK2 showed the highest cell type-specific expression profile. The color of the dots represents the adjusted P values.
