Extended Data Fig. 9: Clonal heterogeneity of chromosomal gains and losses in cancer cells.
From: Ovarian cancer mutational processes drive site-specific immune evasion
a, Copy number heatmap shows chromosomal gains and losses in cancer cells. Each column corresponds to an individual cell grouped by patient (x-axis), and chromosomes are arranged vertically (y-axis). Each patient’s dataset is downsampled to 50 cancer cells to facilitate visualization of the whole cohort. b, Examples of copy number heatmaps for all cancer cells from three patients. Rows correspond to individual cells grouped by patient (y-axis), and chromosomes are arranged horizontally (x-axis). c, Median JAK-STAT pathway activity in cancer cells, aggregated by patient (x-axis). From top to bottom (y-axis), median pathway scores are shown for cells grouped by inferCNV clone (top), transcriptional cancer cell cluster (middle) and median across all cancer cells (bottom).
