Extended Data Fig. 2: The microbiome impact on exercise performance.
From: A microbiome-dependent gut–brain pathway regulates motivation for exercise
a, Ranked plot of treadmill distance of DO mice, with and without antibiotic (Abx) treatment. b-d, Kaplan-Meier plots for distance (b) and time (c) to exhaustion, and time quantification (d) for treadmill exercise of DO mice, with and without Abx treatment. e-h, Quantifications (e, g, h) and Kaplan-Meier plot (f) of treadmill distance (e), time (f, g) and energy (h) of antibiotics (Abx)-treated female mice. i, Wheel running quantification of Abx-treated mice. j-m, Quantifications (j, l, m) and Kaplan-Meier plot (k) of treadmill distance (j), time (k, l) and energy (m) of germ-free (GF) mice. n, Wheel running quantification of GF mice. o-s, Kaplan-Meier plots (o, q) and quantifications (p, r, s) of treadmill distance (o, p), time (q, r) and energy (s) of Abx-treated male mice. t-w, Kaplan-Meier plots (t, v) and quantifications (u, w) of distance (t, u) and time (v, w) on treadmill of Abx-treated mice or mice after Abx cessation (ex-Abx). x-aa, Kaplan-Meier plots (x, z) and quantifications (y, aa) of distance (x, y) and time (z, aa) on treadmill of GF mice and conventionalized (ex-GF) mice. Error bars indicate means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Exact n and p-values are presented in Supplementary Table 2.
