Extended Data Fig. 5: Representative histopathologic findings in COVID-19 autopsy patients.
From: SARS-CoV-2 infection and persistence in the human body and brain at autopsy
(a) Lung, Subject P22, exudative phase diffuse alveolar damage with hyaline membranes and mild interstitial inflammation (H&E, 100x), (b) Lung, Subject P26, proliferative phase diffuse alveolar damage and sparse inflammation (H&E, 200x), (c) Lung, Subject P22, organizing thrombus in medium sized pulmonary artery (H&E, 40x), (d) Lung, Subject P28. Diffuse pulmonary hemorrhage (H&E, 100x), (e) Heart, Subject P3, active lymphocytic myocarditis with cardiomyocyte necrosis (H&E, 400x), (f) Heart, Subject P38, microscopic focus of bland myocardial contraction band necrosis (H&E, 400x), (g) Liver, Subject P41, steatohepatitis with mild steatosis and scattered ballooned hepatocytes (H&E, 400x), (h) Liver, Subject P41, focal bridging fibrosis involving central hepatic veins (Masson trichrome, 40x), (i) Kidney, Subject P16, nodular glomerulosclerosis (Masson trichrome, 600x), (j) Spleen, Subject P16, preservation of white pulp and congestion (H&E, 40x), (k) Spleen, Subject P14, lymphoid depletion of white pulp with proteinaceous material and red pulp congestion (H&E, 100x), (l) Spleen, Subject P34, relative preservation of white pulp with extramedullary hematopoiesis (inset) in red pulp (H&E, 200x), (m) Lymph node, Subject P25, follicular hyperplasia with well-defined follicles (H&E), (n) Lymph node, Subject P25, marked plasmacytosis in the medullary cord (H&E, 400x), (o) Lymph node, Subject P25, marked plasmacytosis and sinus histiocytosis (H&E, 400x), (p) Brain, Subject P35, focal subarachnoid and intraparenchymal hemorrhage (H&E, 40x), (q) Brain, Subject P44, vascular congestion (H&E, 40x), (r) Brain, Subject P43, intravascular platelet aggregates (anti-CD61 stain, 100x). All H&E (and Masson trichrome) photomicrographs are exemplars of histopathology observed across a diversity of patients within the cohort, see Extended Data Table 4 for a summary of histopathology observed across the autopsy cohort and Supplemental data 2b for individual case-level data. The histopathologic observations were validated by a minimum of two board certified anatomic pathologist.
