Extended Data Fig. 4: Multi-neighbourhood community analysis of the intestine.

A) Community analysis was done by taking a window across neighbourhood maps and vectorizing the number of each neighbourhood type in each window, clustering windows, and assigning clusters as multi-neighbourhood communities of the intestine. 10 unique intestinal multi-neighbourhood communities (y axis of heatmap) were defined by enriched neighbourhood types (x axis of heatmap) as compared to overall percentage of neighbourhood types in the samples. B) Quantification of neighbourhood types across each section of the intestine (colour legend within panel A). C) Community percentages as a percent of all communities for small intestine and colon (* p value< 0.05, ** p value< 0.01, *** p value < 0.001, n = 8 donors). D) Concentric multi-neighbourhood analysis surrounding only neighbourhoods labelled as Paneth Cell Enriched neighbourhoods, with number of nearest neighbours for a given row in the heatmap.