Extended Data Fig. 7: Panorama of DNA methylation status and readthrough RNA expression levels of 48 rc-L1s.
From: Widespread somatic L1 retrotransposition in normal colorectal epithelium
DNA methylation status, readthrough RNA expression levels, and developmental phylogenies of 48 rc-L1s in 132 normal colorectal clones and 7 fibroblast clones from 9 patients are displayed. It includes 27 rc-L1s that were active in our colorectal cohort and 21 rc-L1s that harbour demethylated promoters in at least five colorectal clones. The phylogenies are shown on the left side with the number of point mutations (molecular time). PAF, population allele frequency; FPKM, fragments per kilobase of transcript per million; rc-L1, retrotransposition-competent L1.
