Extended Data Fig. 7: Onset of positive selection events at SARS-CoV-2 reQTLs.
From: Dissecting human population variation in single-cell responses to SARS-CoV-2
a and b, Estimated period of selection over the past 2,000 generations, for 148 and 279 SARS-CoV-2 reQTLs with significant evidence of natural selection in Central Africans and West Europeans, respectively (max. |Z-score| > 3). In both panels, variants presenting strong signals of positive selection (i.e., top 5% for PBS) are shown in colour. The transparent rectangle highlights the period between 770 and 970 generations ago (i.e., 21.5-27.2 thousand years ago) associated with genetic adaptation targeting host coronavirus-interacting proteins in East Asians. Variants are ordered along the x-axis in descending order of time to onset of natural selection. c, Percentage of SARS-CoV-2-specific reQTLs presenting selection signals in different populations, between 770 and 970 generations ago. Data are presented as the median and 2.5th −97.5th percentiles (95% CIs) of percentages observed over N = 1,000 resamplings. d and e, Examples of SARS-CoV-2-induced reQTLs at LILRB1 (rs4806787) in plasmacytoid dendritic cells (pDCs) and SIRPA (rs1028396) in CD14+ monocytes. Student’s two-sided t-test p-values < 0.01 are shown; middle line: median; notches: 95% CIs of median, box limits: upper and lower quartiles; whiskers: 1.5× interquartile range; points: outliers. The number n of independent biological samples is indicated where relevant.
