Extended Data Fig. 3: Overlay of WT Mpro-nirmatrelvir complex structure and T21I-nirmatrelvir complex structure (a) or T21I/E166V-nirmatrelvir complex structure (b).
From: Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir
Protomer A of WT Mpro is colored white and protomer B of WT Mpro is colored black, nirmatrelvir in WT Mpro-nirmatrelvir complex structure is shown as green sticks, protomer A of the mutant structure is colored marine and protomer B of the mutant structure is colored orange, nirmatrelvir in mutant Mpro-nirmatrelvir complex structure is shown as red sticks.
