Extended Data Fig. 4: Neutralizing titers of nasal swabs after repeated Omicron infections.
From: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
a, Comparison of nasal swab neutralizing titers among repeated Omicron infection cohorts. Nasal swab antibody titers against pseudotyped variants were measured. Fold changes between titers of different cohorts were calculated and shown above the line. Statistical significance was determined using the two-tailed Wilcoxon rank sum test. Geometric mean ± SD are labeled. b-d, Nasal swab antibody titers against pseudotyped D614G and variants after (b) BA.1 BTI + BA.5/BF.7 infection (n = 26), (c) BA.2 BTI + BA.5/BF.7 infection (n = 19), (d) BA.1/BA.2 + BA.5 infection (n = 12). n’ refers to the number of individuals. Fold changes between titers against variants and D614G were calculated and shown above the line. Statistical significance was determined using the two-tailed Wilcoxon signed-rank test in (b-d). e, Comparison of nasal swab antibody titers against pseudotyped D614G and variants among one-time breakthrough infection and repeated infection cohorts. Statistical significance was determined using the two-tailed Wilcoxon rank sum test in (e). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, and not significant (NS) p > 0.05.
