Fig. 5: Estimation of the evolutionary trends of XBB.1.5 RBD from DMS profiles.
From: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
a,b, Normalized average DMS escape scores weighted by IC50 against XBB.1.5 using DMS profiles of monoclonal antibodies from BA.5/BF.7 BTI (a), and monoclonal antibodies from BA.5/BF.7 BTI and BA.1/BA.2 BTI with BA.5/BF.7 reinfection (b). The effects of each mutation on ACE2 binding and RBD expression and the codon constraints on each residue are also considered (Methods). Residues with high estimated preferences are labelled, and their corresponding mutation scores are shown as logos.
