Extended Data Fig. 2: Neutralizing antibody response after CoronaVac priming and two-dose variant spike booster or two-dose variant spike priming.
From: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
a, Comparison of neutralizing titers after CoronaVac priming and one-dose or two-dose variant spike boosting. b, D614G and boosting variant neutralizing titers after CoronaVac priming and two-dose variant spike boosting. c-d, Comparison of neutralizing titers after CoronaVac priming and variant spike protein or mRNA boosting. one-dose boosting in c and two-dose boosting in d. e, Neutralizing antibody titers after CoronaVac priming and one-dose or two dose variant spike mRNA boosters. f, Neutralizing antibody titers after two-dose variant spike mRNA or protein boosters. 10 mice were immunized and analyzed in each group (n = 10), and all neutralization assays were conducted in at least two independent experiments. Sera were collected four weeks after the last dose. Geometric mean titers (GMT) were labeled. All neutralization assays were conducted in at least two independent experiments. Statistical significance was determined using the two-tailed Wilcoxon rank sum test (a, c, d and f) or two-tailed Wilcoxon signed-rank test (b and e). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, and not significant (NS) p > 0.05.
