Extended Data Fig. 1: sCD4 and sCD4 + 17b induce gp120 shedding on HIV-1BaL virions. | Nature

Extended Data Fig. 1: sCD4 and sCD4 + 17b induce gp120 shedding on HIV-1BaL virions.

From: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes

Extended Data Fig. 1

Western blotting analysis for gp120, gp41 and p24 in the supernatant (S) and pellet (P) fractions of HIV-1BaL viruses from ultracentrifugation after incubation with PBS, sCD4 alone, sCD4 in combination with 17b Fab, or MLV-CD4 VLPs. Residual 17b Fc fragments in 17b Fab were detected by anti-Human 2nd HRP-antibody (grey).

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