Extended Data Fig. 3: Mutational effects of agonists and MD simulation analysis of TAAR1.
From: Recognition of methamphetamine and other amines by trace amine receptor TAAR1
(a) Concentration–response curves of wild-type/mutants of TAAR1 induced by the four agonists. Every response of mutant was normalized to corresponding wild-type as 100%. Data are mean ± S.E.M. from 3 independent experiments (n = 3). (b-c) RMSD plot of METH (b) or β-PEA (c) in TAAR1 pocket during simulations. (d) The free energy contribution of key residues in TAAR1 pocket for METH or β-PEA binding. Data are mean ± S.E.M. from 6 independent experiments (n = 6).
