Fig. 3: Regulatory signalling pathways modulated by endurance training.
From: Temporal dynamics of the multi-omic response to endurance exercise training
a, Transcription factor motif enrichment analysis of the training-regulated transcripts in each tissue. The heat map shows enrichment z-scores across the differential genes for the 13 tissues that had at least 300 genes after mapping transcript IDs to gene symbols. Transcription factors were hierarchically clustered by their enrichment across tissues. CRE, cAMP response element. b, Estimate of activity changes in selected kinases and signalling pathways using PTM signature enrichment analysis on phosphoproteomics data. Only kinases or pathways with a significant difference in at least one tissue, sex or time point (q value < 0.05) are shown. The heat map shows normalized enrichment score (NES) as colour; tissue, sex and time point combinations as columns, and either kinases or pathways as rows. Kinases are grouped by family; rows are hierarchically clustered within each group. FSH, follicle-stimulating hormone; TSH, thyroid-stimulating hormone.
