Fig. 4: Association of SBS40b signature attribution with incidence of kidney cancer.
From: Geographic variation of mutagenic exposures in kidney cancer genomes
a, Number of mutations attributed to signature SBS40b against ASR of kidney cancer in each of the 11 countries represented in the cohort. Data are mean ± s.e.m. (n = 961 biologically independent samples examined over 1 independent experiment). b, Number of mutations attributed to signature SBS40b in four regions of Czech Republic against ASR of kidney cancer in each region. Data are mean ± s.e.m. (n = 961 biologically independent samples examined over 1 independent experiment). a,b, P values are shown for the ASR variable in linear regressions across all cases, adjusted for sex and age of diagnosis. c, Attribution of SBS40b signature within the Czech Republic, with bar plots showing the number of cases for each quartile of SBS40b attribution across Prague, Olomouc, Ceske Budejovice and Brno regions.
