Extended Data Fig. 1: Mutation burdens in clear cell renal cell carcinomas across countries.

Mutation burdens for single base substitutions (SBS) (a), doublet base substitutions (DBS) (b) and small insertions and deletions (ID) (c) show significant differences between countries using the Kruskal-Wallis (two-sided) test (n = 961 biologically independent samples over 1 independent experiment). Four SBS hypermutators and four ID hypermutators above mutation burden of 30000 and 3000, respectively, were removed for clarity. Box and whiskers plots are in the style of Tukey. The line within the box is plotted at the median while the upper and lower ends are indicated 25th and 75th percentiles. Whiskers show 1.5*IQR (interquartile range) and values outside it are shown as individual data points.