Extended Data Fig. 2: Principal component analysis of relative mutation counts.
From: Geographic variation of mutagenic exposures in kidney cancer genomes
PCA performed on relative mutation counts of all ccRCC tumors incorporating the six mutation classes (C > A, C > G, C > T, T > A, T > C, T > G). Principal component 1 (PC1) clearly separates the cluster of mostly Romanian cases that are enriched with AA signatures, often at high mutation burdens. Principal component 3 (PC3) identifies a cluster of mostly Japanese cases, enriched with signature SBS12.
