Extended Data Fig. 6: Shared and distinct programs of gene expression across lesion compartments.
From: Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica
a, Left, total number of differentially expressed genes detected within each lesion compartment at 7 days and 2 months after SCI. Right, legend showing the position of each lesion compartment, as in Fig. 6c. b-c, Volcano plots showing differentially expressed genes for all lesion compartments at 7 days, b, and 2 months, c. The top three genes per lesion compartment, as ranked by the product of the log2-fold change and the –log10 p-value, are annotated. d-e, Heatmap showing log2-fold changes for all genes differentially expressed in at least one lesion compartment at 7 days, d, and 2 months, e. f-g, Heatmap showing log2-fold changes for the top five genes differentially expressed in each lesion compartment at 7 days, f, and 2 months, g. h-i, Visualization of selected differentially expressed genes specific to individual lesion compartments at 7 days, h, and 2 months, i, on the two- dimensional coordinate system of the injured spinal cord.
