Extended Data Fig. 8: Additional characterization of motif groups.

a–r) Morphology of all cells, organized by motif group. Within each group, cells are ordered by soma depth. Colors indicate M-type, darker lines indicate dendrites. s) The arbors of cells extend well beyond the columnar data. The scatterplot depicts a top-down view of soma locations of all synaptic targets of Cell ID 260622. Black dots are cells within the column, red dots are cells outside the column sample; dot size is proportional to number of synapses. t) The number of synapses from each interneuron onto target neurons within the column (black) and anywhere the dataset (red). Interneurons were ordered by within-column synapse count. The mean cell had 5.49 times more synapses across the dataset than onto column targets alone (black dashed line). Only targets passing basic quality control criteria were included. Note that while cells outside the sampled column are not necessarily proofread, synapses onto unproofread dendrites are nearly always correct (see Methods). u) Scatterplot of output synapse budget values within-column and dataset-wide (see v). The blue line indicates equality. The Pearson correlation between within-column measurements with the dataset-wide measurements was R = 0.9, not including trivial zeros (see Methods). v) Output synapse budget for each interneuron onto dataset-wide target M-types, using predictions from perisomatic features from Elabbady et al.⁴⁰. Note that the L6wm M-type was not included in predictions and is thus trivially zero for all interneurons.