Extended Data Fig. 4: Vascular niche- and neuronal subpopulation diversity.
From: Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease
(a,d,g) Subpopulation proportions across participants for (a) vascular niche cells, (d) inhibitory neurons and (g) excitatory neurons. Dots: 465 individual participants, box: 1st and 3rd quartiles, line: median, whiskers extend to the highest and lowest values within 1.5 times the distance between the quartiles. (b,e,h) QC measures. Distributions of number of UMIs and number of Genes detected for each subpopulation of (b) vascular niche, (e) inhibitory neurons and (h) excitatory neurons. (c,f,i) Selected markers and top differentially expressed genes between subpopulations. Gene expression (columns) across subpopulations (rows) of (c) vascular niche, (f) inhibitory neurons and (i) excitatory neurons. Dot colour: mean expression in expressing cells. Dot size: percent of cells expressing the gene.
