Extended Data Fig. 7: Chromatin loop dynamic across cell types and developmental stages.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a) Correlation between the number of cells in each cell population and the number of chromatin loops identified. (b-f) Aggregated chromatin contact signals at differential loops identified across cell types in the adult brain (b), cell types in the mid-gestational brain (c), developmental stages for the Exc-UL trajectory (d), developmental stages for the astrocyte trajectory (e), and subtypes of MGE derived inhibitory neurons in the infant brain (f). The value above each aggregated profile indicates the APA score to evaluate the enrichment of identified loops with respect to the lower left background. (g) Numbers of gain or lost loops across the trajectories of cell type differentiation. (h) Identification of SIPs in PFC-2T-RG-1. (i) Gene expression patterns of the top 250 genes whose promoter is associated with the highest cumulative loop scores in PFC-2T-RG-1. (j) Identification of SIPs in PFC-adult-Exc-UL. (k) Gene expression pattern of top 250 genes whose promoter associated with the highest cumulative loop scores in PFC-adult-Exc-UL. (l) Chromatin loops dynamics at POU3F3 (BRN1) and KHDRBS3 (SLM2) loci across developmental stages. (m) Identification of dev-SIPs associated with the differentiation of Exc-UL. Gene expression patterns of dev-SIPs showing either developmental increase or decrease of loop scores were shown on the left.
