Extended Data Fig. 9: Cell-type and developmental dynamics of chromatin ___domain boundaries.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a) Aggregated chromatin contact signals at differential chromatin ___domain boundaries identified in the differentiation of Exc-UL and Astro. The value above each aggregated plot indicates 1/(insulation score), so a greater score indicates stronger insulation. (b) Numbers of gain or lost ___domain boundaries across the trajectories of cell type differentiation. (c) non-CG methylation level at ___domain boundaries identified for each cell type trajectory. Analysis of true boundaries (solid lines) shuffled (dashed lines). (d-e) Differential chromatin ___domain boundaries were identified during the differentiation of astrocytes at SLC1A2 (d) and SOX11 (e) loci.
