Extended Data Fig. 4: Remodeling of global chromatin conformation during human brain development.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a) Merged chromatin interaction profiles of even clusters identified in Fig. 3a. (b) Distribution of the distance between interaction loci of clusters identified in Fig. 3a. (c) Empirical p-values for the difference in distances of chromatin contact between pairs of clusters in Fig. 3a and Extended Data Fig. 4a. (d) Percentage of each brain cell type assigned to clusters identified in Fig. 3a. (e) Cell-type specific enrichments of SE (Short-range interaction Enriched), LE (Long-range interaction Enriched), and INT (Intermediate) chromatin conformation. (f) Percentage of each brain cell type classified as SE, LE, or INT conformation. (g-k) Remodeling of global chromatin conformation during the differentiation of Exc-CA-1 (g), Exc-DG (h), Inh-MGE-ERBB4 (i), Inh-CGE-CHRNA2 (j), and MGC-1 & MGE-2 (k).
