Fig. 1: Working with neuronal meshes from large-volume electron microscopy segmentations.

a, The MICrONS Minnie65 volume is an approximately 1,300 × 820 × 520 μm³ rectangular volume from mouse visual cortex; H01 is a wedge-shaped volume from human temporal cortex with a longest dimension of 3 mm, a width of 2 mm and a thickness of 150 μm. b–e, The range of accuracy across neural reconstructions in the MICrONS and H01 volumes. b, Example of a nearly complete (manually proofread) single neuron. c, A mesh containing two merged neurons from the MICrONS volume. d, Example of an orphan merge error with a piece of dendrite incorrectly merged onto a neuron mesh. e, An incompletely reconstructed neuron from the H01 volume. f, An overview of the NEURD workflow: starting from volumes and their initial mesh states (Fig. 1), to the processing pipeline (Fig. 2), automatic proofreading (Fig. 3), and cell typing (Supplementary Fig. 12), which then enables the analysis of morphology (Fig. 4), connectomics, and functional connectomics (Fig. 5).