Extended Data Fig. 4: TadA-8e V106W analysis for SaCas9 and LbCas12a. | Nature Biotechnology

Extended Data Fig. 4: TadA-8e V106W analysis for SaCas9 and LbCas12a.

From: Phage-assisted evolution of an adenine base editor with improved Cas ___domain compatibility and activity

Extended Data Fig. 4

a, DNA editing comparing SaABE7.10, SaABE8e, and SaABE8e(TadA-8e V106W) at four genomic sites in HEK293T cells. b, DNA editing comparing LbABE7.10, LbABE8e, and LbABE8e(TadA-8e V106W) at six genomic sites in HEK293T cells. For all plots, dots represent individual biological replicates and bars represent mean±s.d. of three independent biological replicates.

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