Extended Data Fig. 7: BE-eVLPs benefit from the engineered architectures of v3 and v3b PE-eVLPs. | Nature Biotechnology

Extended Data Fig. 7: BE-eVLPs benefit from the engineered architectures of v3 and v3b PE-eVLPs.

From: Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Extended Data Fig. 7

a-c, Comparison of base editing efficiencies of (a) ABE8e, (b) ABE7.10-NG, and (c) TadCBE at the BCL11A locus in HEK293T cells treated with eVLPs that use the v4 BE-eVLP architecture, the v3 PE-eVLP architecture, or the v3b PE-eVLP architecture. Values shown in all graphs represent the average base editing efficiency of three biological replicates and error bars represent the standard deviation. Data were fitted to four-parameter logistic curves using nonlinear regression.

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