Extended Data Fig. 8: Molecular glues and PRMT5 inhibitors.
From: Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics
a) Schematic representation of the RING-CUL4A-DDB1-CRBN complex with a bound IMiD molecular glue. b, c) Dose-dependent protein expression for GLUL and ORAI1 in response to several IMiDs. d) same as b) but for members of the RING-CUL4A-DDB1-CRBN complex. e) Same as b) but for IKZF2, PATZ1 and RAB28. f) Far left panel: schematic representation of SNRPB methylation by PRMT5 and its inhibition by pemrametostat and onametostat. Middle left panel: apparent upregulation of SNRPN and SNRPB by several PRMT5 inhibitors. Right two panels: Down-regulation of methylated Arg108 and Arg147 of SNRPB by PRMT5 inhibitors.
