Developers are recombining or sharpening established drugs, molecules and mechanisms to create a new generation of neurology therapies.
Login or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Change history
21 May 2025
In the version of the article initially published, the source for the graph used in Fig. 1 was missing and is now restored in the HTML and PDF versions of the article.
References
Harrison, C. Nat. Biotechnol. 43, 287–289 (2025).
McDermott, L. A. et al. Neuron https://doi.org/10.1016/j.neuron.2019.01.047 (2019).
Knowland, D. et al. J. Clin. Invest. https://doi.org/10.1172/JCI140311 (2020).
Wieskopf, J. S. et al. Sci. Transl. Med. https://doi.org/10.1126/scitranslmed.3009986 (2015).
Conaghan, P. et al. In ACR Convergence 2024 https://acrabstracts.org/abstract/levi-04-a-novel-neurotrophin-3-inhibitor-substantially-improves-pain-and-function-without-deleterious-effects-on-joint-structure-in-people-with-knee-osteoarthritis-a-randomized-controlled-phase-ii/ (2024).
Zhang, M. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-023-01464-x (2023).
Khairatkar-Joshi, N. & Szallasi, A. Trends Mol. Med. https://doi.org/10.1016/j.molmed.2008.11.004 (2009).
Finol-Urdaneta, R. K. et al. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.2110932119 (2022).
Cao, B. et al. Signal Transduct. Target. Ther. https://doi.org/10.1038/s41392-024-01845-w (2024).
Gahr, M., Kratzer, W., Fuchs, M. & Connemann, B. J. et al. Curr. Drug Metab. https://doi.org/10.2174/1389200215666140926155041 (2014).
Bremova-Ertl, T. et al. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2310151 (2024).
Churchill, G. C., Strupp, M., Galione, A. & Platt, F. M. et al. PLoS One https://doi.org/10.1371/journal.pone.0229585 (2020).
Oertel, W. H. et al. Nat. Commun. https://doi.org/10.1038/s41467-024-51502-7 (2024).
Al-zharani, M., Hasnain, M. S., Al-Eissa, M. S. & Alqahtani, R. A. et al. J. King Saud Univ. Sci. https://doi.org/10.1016/j.jksus.2024.103513 (2024).
Razavi, R., Khajouei, G., Divsalar, F., Dawi, E. & Amiri, M. et al. Rev. Neurosci. https://doi.org/10.1515/revneuro-2024-0086 (2024).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Senior, M. Precision neuroscience. Nat Biotechnol 43, 659–664 (2025). https://doi.org/10.1038/s41587-025-02673-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41587-025-02673-1